Research interests
• Identifying disease-relevant genomic loci and pinpointing causal variants by integrating GWAS and other omics data.
• Integrating human genetics and single-cell data to reveal candidate genes and their involved biological pathways and cell types associated with complex diseases.
• Investigating the interplay between human genetics and environmental factors to understand their combined effects on diseases.
Selected Publications
• Jingjing Li, Yunlong Ma, Yue Cao, Gongwei Zheng, Yijun Zhou, Yaru Zhang, Chunyu Deng, Weihua Chen, Jianzhong Su, Integrating microbial GWAS and single-cell transcriptomics reveals associations between host cell populations and the gut microbiome. Nature Microbiology (2025).
• Yongxian Hu, Jingjing Li (co-first author), Fang Ni, Zhongli Yang, Xiaohua Gui, Zhiwei Bao, Houli Zhao, Guoqing Wei, Yiyun Wang, Mingming Zhang, Ruimin Hong, Linqin Wang, Wenjun Wu, Mohamad Mohty, Arnon Nagler, Alex H. Chang, Marcel R. M. van den Brink, Ming D, Li, He Huang; CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies, Nature Communications, 2022, 13(1).
• Zhongli Yang, Jingjing Li (co-first author), Xiaohua Gui, et. al., Updated review of research on the gut microbiota and their relation to depression in animals and human beings, Molecular Psychiatry, 2020, 25(11): 2759-2772.
• Yunlong Ma, Yinghao Yao, Yijun Zhou, Wei Dai, Jingjing Li, Yuanyuan Gui, Haojun Sun, Zhengbiao Zhu, Dingping Jiang, Cheng Chen, Chunyu Deng, Yizhou Huang, Haijun Han, Jianhong Zhou, Jianzhong Su. Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune-and aging-related diseases. Nature Aging (2026).
• Yunlong Ma, Chunyu Deng, Yijun Zhou, Yaru Zhang, Fei Qiu, Dingping Jiang, Gongwei Zheng, Jingjing Li, Jianwei Shuai, Yan Zhang, Jian Yang, and Jianzhong Su, Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data. *Cell Genomics, 2023 August 18. 3(9):100383.
Research Fundings
• China Postdoctoral Science Funding.